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                  <text>KTI D-III Farmasi</text>
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                <text>FORMULASI DAN EVALUASI EKSTRAK ETANOL BUNGA TELANG (Clitoria ternatea L.) SEBAGAI TABIR SURYA DALAM SEDIAAN SPRAY GEL DENGAN VARIASI CARBOPOL 940 DAN HPMC SEBAGAI GELLING AGENT</text>
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                <text>ABSTRAK&#13;
Latar Belakang: Spray gel merupakan sediaan semi padat terbuat dari molekul&#13;
organik yang besar atau partikel anorganik yang kecil dan terpenetrasi oleh cairan&#13;
dengan menerapkan teknik penyemprotan dari tetesan cairan berukuran kecil atau&#13;
besar dan ditetapkan melalui media aerosol atau pompa semprot. Spray gel&#13;
memiliki keunggulan cepat kering, mudah digunakan, aman, dan praktis.&#13;
Penggunaan carbopol sebagai gelling agent dapat menghasilkan gel yang jernih,&#13;
lalu HPMC dapat menghasilkan gel yang netral dan stabil dalam jangka waktu&#13;
lama sehingga kombinasi keduanya sebagai basis akan menghasilkan gel yang&#13;
lebih baik secara fisik. Penelitian ini bertujuan untuk mengetahui konsentrasi&#13;
Carbopol dan HPMC yang tepat sehingga menghasilkan sediaan yang stabil&#13;
secara fisik dan memenuhi persyaratan. Spray gel dibuat menggunakan zat aktif&#13;
bunga telang (Clitoria ternatea L.) dengan kandungan senyawa aktif flavonoid&#13;
khususnya antosianin yang merupakan agen fotoprotektif sebagai tabir surya.&#13;
Metode: Penelitian ini menggunakan metode eksperimental, dimana ekstrak&#13;
etanol bunga telang (Clitoria ternatea L.) diformulasikan menjadi sediaan Spray&#13;
gel dengan variasi konsentrasi Carbopol dan HPMC. Konsentrasi zat aktif yakni&#13;
5% dan variasi konsentrasi Carbopol dan HPMC yang digunakan adalah&#13;
0,5%:0,5%, 1%:0,5%, dan 0,5%:1%. Kemudian dilakukan evaluasi sediaan pada&#13;
suhu kamar dan uji dipercepat (cycling test) meliputi pH, homogenitas, daya&#13;
sebar, kondisi semprotan, viskositas, perubahan warna, bau, iritasi kulit, dan nilai&#13;
SPF.&#13;
Hasil: Hasil evaluasi menunjukkan bahwa sediaan Spray gel memiliki pH yang&#13;
cenderung meningkat, memiliki homogenitas yang baik, viskositas yang&#13;
memenuhi syarat, memiliki daya sebar yang meningkat namun masih memenuhi&#13;
syarat dan kondisi semprotan yang baik. Semua sediaan Spray gel tidak&#13;
mengalami perubahan bau, warna, dan tidak terjadi iritasi kulit saat pengujian&#13;
selama penyimpanan suhu kamar dan cycling test. Serta memiliki nilai SPF yang&#13;
tergolong ekstra.&#13;
Kesimpulan:Ekstrak etanol bungatelang(Clitoria ternatea L.)dapat&#13;
diformulasikan menjadi sediaan spray gel yang stabil dan memenuhi syarat.&#13;
Formula yang paling optimal adalah formula II dengan variasi konsentrasi&#13;
Carbopol dan HPMC 1% dan 0,5%.&#13;
Kata kunci: Bunga telang (Clitoria ternatea L.), spray gel, Carbopol, HPMC</text>
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                <text>Aziz Muhammad Rifqy Irawan</text>
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                <text>Poltekkes Kemenkes Palembang Jurusan Farmasi</text>
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                <text>GAMBARAN KEBERADAAN JAMUR MALASSEZIA FURFUR PADA ANAK-ANAK PANTI ASUHAN DI KECAMATAN SUKARAMI KOTA PALEMBANG TAHUN 2023</text>
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                <text>Malassezia furfur merupakan jenis jamur yang dapat&#13;
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AMAN DAN NYAMAN (TERINTEGRASI SDKI, SLKI,&#13;
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Indonesian natural school in Palembang and at the school&#13;
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