Dublin Core
Title
The Effect of Kerokan to Liver Function of Hepatitis B Patients
Subject
Hepatitis B, kerokan, SGOT, SGPT
Description
Kerokan is an alternative therapy done by rubbing and pressing the skin surface using oil and a blunt object. This
treatment has a hepatoprotective effect as it increases heme oxygenase-1, an essential enzyme in heme catabolism.
In hepatitis B, heme oxygenase-1 plays a vital role to fight oxidative stress. Hence the damage on liver cells can be
reduced or even prevented. Damaged cells indicate by the production of aspartate aminotransferase (AST/SGOT)
and alanine aminotransferase (ALT/SGPT) enzymes that accumulated in the bloodstream. This study aimed to
investigate the effect of kerokan to liver function by analyzing SGOT and SGPT levels in hepatitis B patients. These
were an experimental study with a pre-test post-test control group design conducted in the public health center in
Palembang in October 2016. Statistical analysis used the unpaired t test and paired. The research subjects were
30 patients with inactive carrier and chronic hepatitis B. The levels of SGOT and SGPT were determined using the
IFCC method. The levels of SGOT in control (19.53±3.44 U/L) and treatment group (20.46±4.53 U/L, Δ=0.93) after
24–48 hours were not statistically different (p=0.53). Also, the levels of SGPT in control (18.66±5.40 U/L) and
treatment group (19.80±9.25 U/L, Δ=1.13) after 24–48 hours were also not statistically different (p=0.68) as well.
In conclusion, the liver cells of inactive carrier and chronic hepatitis B patients were not damaged (necrosis) after
kerokan therapy, and the levels of SGOT and SGPT were still in the normal range.
treatment has a hepatoprotective effect as it increases heme oxygenase-1, an essential enzyme in heme catabolism.
In hepatitis B, heme oxygenase-1 plays a vital role to fight oxidative stress. Hence the damage on liver cells can be
reduced or even prevented. Damaged cells indicate by the production of aspartate aminotransferase (AST/SGOT)
and alanine aminotransferase (ALT/SGPT) enzymes that accumulated in the bloodstream. This study aimed to
investigate the effect of kerokan to liver function by analyzing SGOT and SGPT levels in hepatitis B patients. These
were an experimental study with a pre-test post-test control group design conducted in the public health center in
Palembang in October 2016. Statistical analysis used the unpaired t test and paired. The research subjects were
30 patients with inactive carrier and chronic hepatitis B. The levels of SGOT and SGPT were determined using the
IFCC method. The levels of SGOT in control (19.53±3.44 U/L) and treatment group (20.46±4.53 U/L, Δ=0.93) after
24–48 hours were not statistically different (p=0.53). Also, the levels of SGPT in control (18.66±5.40 U/L) and
treatment group (19.80±9.25 U/L, Δ=1.13) after 24–48 hours were also not statistically different (p=0.68) as well.
In conclusion, the liver cells of inactive carrier and chronic hepatitis B patients were not damaged (necrosis) after
kerokan therapy, and the levels of SGOT and SGPT were still in the normal range.
Creator
Nur Adiba Hanum, Ismalayani, Rahmad Aswin Juliansyah, Syokumawena,
Marta Pastari, Hanna Sari Widya Kusuma, Yukko Arinta
Marta Pastari, Hanna Sari Widya Kusuma, Yukko Arinta
Publisher
Politeknik Kesehatan Palembang
Date
2019
Format
pdf
Language
English
Type
Jurnal Internasional