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                  <text>KTI D-III Farmasi</text>
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                  <text>Umar Akhmad</text>
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                <text>FORMULASI SEDIAAN HAIR TONIC KOMBINASI EKSTRAK DAUN TEH (Camelia sinensis (L.) DENGAN HERBA PEGAGAN (Centella asiatica (L.)Urban) DAN  UJI KESTABILAN FISIKNYA</text>
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                <text>Latar Belakang &#13;
Manusia memiliki berbagai macam anggota tubuh yang selalu diperhatikan. &#13;
Salah satunya adalah rambut. Rambut pada manusia hampir tumbuh di setiap &#13;
bagian tubuh, namun terdapat bagian-bagian tertentu dari tubuh manusia yang &#13;
ditumbuhi rambut lebat atau banyak, misalnya kulit kepala manusia, ketiak, dan &#13;
kemaluan. Namun, yang sering diperhatikan adalah rambut kepala. Salah satu &#13;
peranannya adalah berfungsi sebagai proteksi terhadap lingkungan luar, seperti &#13;
suhu dingin atau panas. Pada manusia, rambut tidak hanya bersifat sebagai &#13;
pelindung tetapi juga berperan menunjang penampilan bagi wanita (Nusmara, &#13;
2012), atau dikenal dengan julukan ”mahkota”. Namun julukan tersebut tidak lagi &#13;
tertuju hanya kepada kaum wanita, namun juga pria (Angendari, 2015). &#13;
Rambut mengalami proses pertumbuhan dan kerontokan setiap helainya. &#13;
Meskipun kerontokan alami dari rambut, namun terkadang kuantitas dan frekuensi &#13;
kerontokan menjadi meningkat sehingga terjadi kebotakan (Nusmara, 2012). &#13;
Kebotakan biasanya terjadi oleh kondisi fisiologis, stress emosional maupun fisik, &#13;
usia lanjut, depresi, berkurangnya aktifitas kelenjar minyak dikulit kepala, &#13;
gangguan pembuluh darah, gangguan hormon, pengaruh kosmetika, pajanan sinar &#13;
matahari secara terus menerus dan kurangnya makanan yang bergizi untuk &#13;
kepentingan pertumbuhan rambut (Harrison, 2009). Apabila hal tersebut tidak &#13;
diperhatikan maka akan memungkinkan terjadinya kerontokan rambut sehingga &#13;
rambut menjadi tipis bahkan botak, rambut rontok, kulit kepala dan rambut&#13;
2&#13;
 &#13;
kering, rambut kusam dan sulit diatur serta timbulnya uban sebelum waktunya &#13;
(Angendari, 2015).  &#13;
Banyak cara untuk mengatasi rambut rontok diantaranya, dengan mengatur &#13;
pola makan yang baik dan teratur, menerapkan gaya hidup yang sehat, melindungi &#13;
rambut dari sinar matahari langsung, pijat kulit kepala perlahan setiap hari, dan &#13;
menggunakan produk bahan alami untuk menstimulus pertumbuhan rambut yang &#13;
dioleskan pada kulit kepala. Bahan alami yang bisa digunakan untuk &#13;
menyuburkan rambut diantaranya lidah buaya, bunga sepatu, ginseng, ginkgo &#13;
biloba, jati putih, tarum, salam koja, gletang, pegagan dan teh (Thorat, 2010).  &#13;
Tanaman teh yang mengandung senyawa kimia theobromin, theofilin, tanin, &#13;
xanthine, adenine, minyak atsiri, kuersetin, naringenin,  natural fluoride, dan &#13;
polifenol berupa flavonoid beserta turunannya (Dalimartha, 1999) secara &#13;
tradisional mempunyai banyak khasiat yaitu digunakan untuk mengatasi diare, &#13;
sakit kepala, mengurangi pembentukan karang gigi, infeksi saluran cerna, &#13;
kolestrol darah tinggi, menghitamkan rambut dan menyuburkan rambut (Yuniarti, &#13;
2008). Polifenol dalam teh lebih dikenal sebagai flavanol atau katekin. Katekin &#13;
utama dalam teh meliputi epikatekin, epikatekin-3-galat, epigalokatekin, dan &#13;
epigalokatekin-3-galat (EGCG) (Chacko et al., 2010). Senyawa epigalocatecin-3-&#13;
gallat (EGCG) yang membuat rambut menjadi subur (Kwon et al., 2007). EGCG &#13;
merupakan senyawa yang memiliki 15 atom C dalam inti dasarnya yang tersusun &#13;
dalam konfigurasi C6-C3-C6 yaitu cincin aromatik yang dihubungkan oleh satuan &#13;
3 karbon yang dapat atau tidak dapat membentuk cincin. &#13;
Pegagan dengan kandungan senyawa utama triterfenoid saponin yaitu &#13;
asiatikoside, flavonoid, fitosterol, madecassid acid, madecassoside, asam asiatik, &#13;
&#13;
 &#13;
3&#13;
 &#13;
asam amino, asam lemak, steroid, tanin, alkaloid (Zheng &amp; Qin, 2007) yang &#13;
mempunyai banyak khasiat yaitu hepatitis, campak, demam, amandel, sakit &#13;
tenggorokan, bronkitis, mata merah, wasir, keracunan, muntah darah, batuk darah, &#13;
mimisan, cacingan, lepra, infeksi dan batu saluran kencing (Yuniarti, 2008), dan &#13;
juga digunakan untuk perawatan rambut rontok (Thorat, 2010). Pada penelitian &#13;
Jain (2011) ekstrak pegagan 5% b/b  yang dikombinasikan dengan ekstrak &#13;
Emblica officinalis 5% b/b, ekstrak Aloe vera 5% b/b,  ekstrak Ocimum sanctum &#13;
5% b/b, ekstrak Eclipta alba 5 % b/b yang berbentuk sediaan salep menunjukkan &#13;
aktivitas sebagai penyubur rambut yang diaplikasikan secara topikal pada tikus.  &#13;
Teh (Camelia sinensis (L.) dan Pegagan (Centella asiatica (L.) Urban) &#13;
merupakan jenis tumbuhan yang mudah diperoleh dan sudah sering digunakan &#13;
secara empiris dalam kehidupan sehari-hari untuk berbagai khasiat (Sulastri, &#13;
Indrawati, &amp; Taurhesia, 2016). Berdasarkan penelitian Sulastri, dkk (2016) bahwa &#13;
kombinasi ekstrak air daun teh (Camelia sinensis (L.) dan herba pegagan &#13;
(Centella asiatica (L.) Urban) mempunyai aktivitas mempercepat pertumbuhan &#13;
rambut dengan konsentrasi esktrak air daun teh (5%) dan ekstrak air herba &#13;
pegagan (2,5%). Berpedoman pada penelitian Sulastri, dkk (2016) dan mengingat &#13;
belum adanya penelitian yang dilakukan untuk memformulasikan kombinasi &#13;
esktrak daun teh (Camelia sinensis (L.) dan ekstrak herba pegagan (Centella &#13;
asiatica (L.) Urban) dalam bentuk sediaan hair tonic, sehingga penelitian ini &#13;
diharapkan dapat diketahui apakah ekstrak daun teh (Camelia sinensis (L.) dan &#13;
ekstrak herba pegagan (Centella asiatica (L.) Urban) dapat diformulasikan &#13;
menjadi sediaan hair tonic yang stabil dan kestabilan fisik yang memenuhi &#13;
persyaratan. </text>
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                <text>RADELLA TRISSIA</text>
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                <text>Poltekkes Kemenkes Palembang Jurusan Farmasi</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2017</text>
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                <text>Pembimbing Utama : Dewi Marlina, SF, Apt, M.Kes </text>
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            <name>Language</name>
            <description>A language of the resource</description>
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                <text>Indonesia</text>
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                  <text>KTI D-III Farmasi</text>
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                <text>FORMULASI SEDIAAN GEL KOMBINASI EKSTRAK DAUN SIRIH MERAH (Piper crocatum Ruiz. and Pav.) DAN EKSTRAK HERBA PEGAGAN (Centella asiatica (L.) Urban) DENGAN VARIASI CARBOPOL 940 SEBAGAI GELLING AGENT</text>
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                <text>Latar Belakang: Daun Sirih Merah (Piper crocatum Ruiz. and Puv.) dan Herba&#13;
Pegagan (Centella asiatica L. Urban) mengandung senyawa aktif flavonoid,&#13;
saponin, dan tanin yang memiliki aktifitas antibakteri, memacu pembentukan&#13;
kolagen dan sebagai astringen. Menurut Dian Reni Agustina (2011) Kombinasi&#13;
daun sirih merah dan herba pegagan berdasarkan akttivitas farmakologi kedua&#13;
tanaman dapat terjadi efek sinergis dan aditif sebagai pengobatan luka pada&#13;
penderita diabetes. &#13;
Metode: Penelitian yang dilakukan adalah eksperimental. Ekstrak daun sirih&#13;
merah (Piper crocatum Ruiz. and Puv.) dan herba pegagan (Centella asiatica L.&#13;
Urban) diformulasikan menjadi sediaan gel dengan memvariasikan konsentrasi&#13;
Carbopol 940. Konsentrasi zat aktif sirih merah dan herba pegagan yang&#13;
digunakan dalam setiap formula masing-masing adalah 25% dan 7,5%  serta&#13;
konsentrasi Carbopol 940 yang digunakan pada formula I adalah 1%, pada&#13;
formulaII adalah 1,5%, pada formula III dan formula kontrol adalah 2%.&#13;
Kemudian dilakukan uji kestabilan fisik dan uji iritasi kulit. Uji kestabilan fisik&#13;
meliputi pH, viskositas, homogenitas, daya sebar, warna dan bau. Pengujian&#13;
dilakukan selama 28 hari penyimpanan. &#13;
Hasil: Selama 28 hari penyimpanan pH gel cenderung stabil, viskositas&#13;
mengalami penurunan sedangkan daya sebar mengalami peningkatan. Partikel&#13;
terdistribusi secara merata serta memiliki warna dan bau yang stabil. Ketiga&#13;
formula tidak menimbulkan iritasi kulit saat diaplikasikan ke kulit. &#13;
Kesimpulan: Kombinasi ekstrak daun sirih merah (Piper crocatum Ruiz. and&#13;
Puv.) dan herba pegagan (Centella asiatica L. Urban) dapat diformulasikan&#13;
menjadi sediaan gel yang stabil dan memenuhi persyaratan. Formula yang paling&#13;
stabil adalah formula II dengan konsentrasi Carbopol 940 sebesar 1,5%. &#13;
Keyword: Formulasi Sediaan Gel Carbopol 940, Daun Sirih Merah (Piper&#13;
crocatum Ruiz. and Puv.), Herba Pegagan (Centella asiatica L. Urban) </text>
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