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                <text>OPTIMALISASI AIR PERASAN BUNGA PUKUL EMPAT (Mirabilis jalapa) SEBAGAI PEWARNA ALTERNATIF PEMERIKSAAN TELUR CACING SOIL TRANSMITTED HELMINTHS (STH)&#13;
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                <text>Latar Belakang: Bunga pukul empat memiliki kandungan utama yaitu antosianin yang berperan dalam pemberi pigmen warna pada bunga, kadar antosianin yang terkandung dalam bunga pukul empat sebesar 0,977% sehingga bunga pukul empat dapat dijadikan pewarna alternatif dalam pemeriksaan telur cacing STH, selain zat perwarnanya yang ramah lingkungan dari segi harga juga lebih ekonomis. Tujuan: Mengetahui optimalisasi air perasan bunga pukul empat (Mirabilis jalapa) sebagai pewarna alternatif pada pemeriksaan telur cacing STH. Metode: Eksperimen dengan desain penelitian Static Group Comparison. Penelitan dilaksanakan pada bulan Februari dengan teknik sampling total sampling. Hasil Penelitian: Hasil uji normalitas data menunjukkan p.value=0,000, karena p&lt;0,05 data dinyatakan berdistribusi tidak normal dan dilanjutkan dengan pengujian hipotesa Kruskal Wallis diperoleh nilai p.value =0,000 yang menunjukkan nilai P&lt;0,05 sehingga dinyatakan adanya perbedaan kualitas pewarnaan air perasan bunga dengan eosin 2%, akan tetapi untuk mengetahui perbedaan antara semua kelompok perlakuan dengan eosin 2% dilakukan uji lanjutan dengan Mann-U Whitney. Dari uji lanjutan air perasan bunga pukul empat dengan konsentrasi 100% didapatkan nilai p&gt;0,05 maka dapat dinyatakan kualitas pewarnaan sama dengan kontrol eosin 2%. Kesimpulan: Air perasan bunga pukul empat dengan konsentrasi 100% dapat dijadikan pewarna alternatif pengganti eosin 2%. Pada pemeriksaan sediaan secara mikroskopis didapatkan lapangan pandang yang kontras, telur cacing yang menyerap warna dan bagian telurnya terihat jelas. </text>
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                <text>OPTIMASI FORMULA BALSEM STIK EKSTRAK RIMPANG BANGLE (Zingiber cassumunar Roxb.) DENGAN BASIS CERA ALBA DAN CETYL ALCOHOL MENGGUNAKAN           METODE SIMPLEX LATTICE DESIGN&#13;
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                <text>Latar Belakang :Metode Simplex Lattice Design (SLD) digunakan untuk menentukan proporsi relatif bahan yang akan digunakan dalam suatu formula, sehingga dapat dihasilkan formula optimal. Metode ini diaplikasikan dalam formula balsem stik dengan basis Cera Alba dan Cetyl Alcohol yang mengandung ektrak rimpang bangle (Zingiber cassumunarRoxb.) untuk mengobati radang sendi.&#13;
&#13;
Metode :Jenis penelitian ini eksperimental menggunakan metode SLD dalam penentuan kombinasi basis Cera Alba dan Cetyl Alcohol. Ekstrak kental rimpang bangle (Zingiber cassumunarRoxb.) diperoleh dengan destilasi vakum dan diformulasikan sebanyak 0,18 gram tiap formulanya. Balsem stik dibuat lima formula dengan konsentrasi Cera Alba dan Cetyl Alcohol 100%:0%, 75%:25%, 50%:50%, 25%:75% dan 0%:100% dengan bantuan aplikasi software Design Expert 11.0, selanjutnya diuji sifat fisik meliputi pH, suhu lebur, homogenitas, daya oles, warna, bau dan iritasi kulit.&#13;
&#13;
Hasil :Hasil uji sifat fisik meliputi pH 4,51-5,89, suhu lebur 51ºC-70ºC, homogenitas formula I sampai V memenuhi syarat. Dari rekapitulasi kuesioner responden untuk hasil uji daya oles, warna, bau dan iritasi kulit tidak mengalami perubahan maupun tidak mengalami iritasi kulit. Formula optimal yang diperoleh terdiri dari cera alba 45,9679% dan cetyl alcohol 54,0321% yang memiliki nilai desirability0,917.&#13;
&#13;
Kesimpulan : Ekstrak Rimpang Bangle (Zingiber cassumunar Roxb.) dapat diformulasikan menjadi sediaan balsem stik dengan sifat fisik yang memenuhi persyaratan dan formula optimal yang diperoleh menggunakan metode SLD terdiri dari Cera alba 45,9676% dan Cetyl alcohol 54,0321% dengan formula optimal yang memiliki pH 5,26513, suhu lebur  59,9001°C dan nilai desirability 0,917.&#13;
&#13;
Kata Kunci :Balsem Stik, Ekstrak Rimpang Bangle (Zingiber cassumunarRoxb.), Cera Alba dan Cetyl Alcohol, Metode Simplex Lattice Design&#13;
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                <text>OPTIMASI FORMULA SALEP EKSTRAK HERBA PAKU SAYUR (Diplazium esculentum S.) BASIS VASELIN FLAVUM DAN ADEPS LANAE DENGAN METODE SIMPLEX LATTICE DESIGN</text>
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                <text>Latar Belakang : Metode Simplex Lattice Design (SLD) digunakan untuk&#13;
menentukan proporsi relatif bahan yang akan digunakan dalam suatu formula,&#13;
sehingga dapat dihasilkan formula optimal. Meteode ini diaplikasikan dalam&#13;
formula salep dengan basis Vaselin Flavum – Adeps Lanae yang mengandung&#13;
ektrak herba paku sayur (Diplazium esculentum S.) untuk mengobati luka sayat.&#13;
Metode : Jenis penelitian ini eksperimental menggunakan metode SLD dalam&#13;
penentuan kombinasi basis Vaselin Flavum dan Adeps Lanae. Ekstrak kental&#13;
herba paku sayur (Diplazium esculentum S.) diperoleh dengan destilasi vakum&#13;
dan diformulasikan sebanyak 2 gram tiap formulanya. Salep dibuat lima formula&#13;
dengan konsentrasi Vaselin Flavum dan Adeps Lanae 100%:0%, 75%:25%,&#13;
50%:50%, 25%:75% dan 0%:100% dengan bantuan aplikasi software Design&#13;
Expert 11.0, selanjutnya diuji sifat fisik meliputi pH, viskositas, daya sebar,&#13;
homogenitas, warna, bau dan iritasi kulit.&#13;
Hasil : Diperoleh rendemen ekstrak herba paku sayur (Diplazium esculentum&#13;
S.) sebesar 13,74%. Hasil uji sifat fisik meliputi pH 4,35-4,54, viskositas 158,46356,83&#13;
dPa,&#13;
&#13;
daya sebar 3,2-5,6 cm, homogenitas formula I sampai V memenuhi&#13;
syarat. Dari rekapitulasi kuesioner responden untuk hasil uji warna, bau dan iritasi&#13;
kulit tidak mengalami perubahan maupun tidak mengalami iritasi kulit. Formula&#13;
optimal yang diperoleh terdiri dari Vaselin Flavum 75,080% dan Adeps Lanae&#13;
24,919% dengan nilai desirability 0.934.&#13;
Kesimpulan : Ekstrak herba paku sayur (Diplazium esculentum S.) dapat&#13;
diformulasikan menjadi sediaaan salep dengan sifat fisik yang memenuhi&#13;
persyaratan dan formula optimal yang diperoleh menggunakan metode SLD&#13;
terdiri dari Vaselin Flavum 75,080% dan Adeps Lanae 24,919% dengan formula&#13;
optimal pH 4,498, daya sebar 5 cm dan viskositas 227,259 dPa dengan nilai&#13;
desirability 0,934.</text>
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larut berkisar 48,67-60,67&#13;
0&#13;
C, keseragaman bobot berkisar 3,149155-3,31665&#13;
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0,928. &#13;
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persyaratan dan formula optimal yang diperoleh menggunakan metode SLD&#13;
terdiri dari PEG 1000 63,028% dan PEG 4000 36,972%.  &#13;
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The Effect of Supportive Educative Cardiac Rehabilitation Phase&#13;
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Heart Disease</text>
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body causes a decrease in the patient’s activity which has an impact on sexual function. The purpose of this study&#13;
&#13;
was to analyse the effect of supportive educative cardiac rehabilitation phase 3 (SE-CRP3) on male sexual dysfunc-&#13;
tion (SD) among patients with Chronic Heart Disease (CHD). Methods: A quasi-experiment study was undertaken&#13;
&#13;
on August 2019. Sixty respondents was recruited by purposive sampling technique and divided into intervention&#13;
and control groups. International Index of Erectile Function Questionnaire (IIEF) was used to obtained the data about&#13;
sexual function. Then, we analysed the data using independent samples t-test and paired samples t-test. Results: We&#13;
found a significant difference between pre and post intervention in the intervention group (p=0.039) with mean of&#13;
&#13;
sexual dysfunction (18.97 to 19.93). In addition, there was no significant difference between pre and post in the con-&#13;
trol group (p=0.152) and no differences in the both groups after the intervention of SE-CRP3 (p=0.568). Conclusion:&#13;
&#13;
SE-CRP3 therapy has an impact on sexual function among patients with CHD. This may be considered by nurses as&#13;
an additional intervention in patients with CHD. Observations on the related variables can be considered.</text>
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                <text>Rehana Rehana1&#13;
&#13;
, Devi Mediarti1&#13;
&#13;
, Jawiah Jawiah1&#13;
&#13;
, Rosnani Rosnani1&#13;
&#13;
, Hidayat Arifin2&#13;
&#13;
, Wahyu Dwi Ari&#13;
&#13;
Wibowo3</text>
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