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                  <text>KTI D-III Kebidanan Muara Enim</text>
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                <text>Ari Kulynia Sari</text>
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                <text>Berdasarkan Survey Demografi dan Kesehatan Indonesia (SDKI) 2012, rata-rata &#13;
angka kematian ibu (AKI) Tercatat mencapai 359 per 100.000 kelahiran hidup. &#13;
Sedangkan SDKI tahun 2017 kematian neonatus sebesar 19 per 1000 KH, &#13;
kematian post neonatus sebesar 13 per 1000 KH dan Angka Kematian Bayi &#13;
(AKB) sebesar 32 per 10.000 KH. Target global MDGs (Millenium Development &#13;
Goals) ke-5 yaitu menurunkan AKI menjadi 102 per 100.000 kelahiran hidup &#13;
pada tahun 2015.(Kemenkes RI 2016). Tujuan penulisan Laporan Tugas Akhir &#13;
ini untuk memberikan asuhan kebidanan secara komprehensif pada Ny F di BPM &#13;
Az-Zahwa Muara Enim Tahun 2019 dengan menggunakan pendekatan &#13;
manajemen kebidanan dan melakukan dokumentasi dalam bentuk SOAP. Desain &#13;
penelitian ini menggunakan metode studi kasus (case study). Teknik pengumpulan &#13;
data yang digunakan adalah wawancara (anamnesis), pemeriksaan fisik (inspeksi, &#13;
palpasi, auskultasi, perkusi), pemeriksaan dalam, pemeriksaan penunjang lainnya &#13;
dan observasi. Hasil asuhan komprehensif ini menunjukkan tadanya kesenjangan &#13;
antara teori dan praktik di lapangan pada asuhan persalinan yaitu pada &#13;
penggunaan alat pelindung diri (APD) yang digunakan kurang lengkap. Melalui &#13;
Laporan Tugas Akhir ini diharapkan bagi pihak petugas kesehatan Az-Zahwa &#13;
dapat mempertahankan dan meningkatkan mutu pelayanan kesehatan sesuai &#13;
standar dalam memberikan asuhan kebidanan yang komprehensif.</text>
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                <text>Hj Mursyida A.W , SKM. M.Kes</text>
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                  <text>KTI D-III Farmasi</text>
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                <text>ARTICLE REVIEW: EKSTRAK TANAMAN HERBAL SEBAGAI ANTIDIABETES PADA HEWAN COBA YANG DIINDUKSI ALOKSAN DAN STREPTOZOTOSIN</text>
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                <text>ABSTRAK&#13;
Latar Belakang: Diabetes melitus adalah salah satu penyakit degeneratif berupa&#13;
gangguan metabolisme yang ditandai dengan peningkatan kadar gula darah atau&#13;
hiperglikemia, kelainan metabolisme karbohidrat, lemak dan protein serta&#13;
peningkatan resiko penyakit kardiovaskuler. Pengobatan penyakit diabetes melitus&#13;
menggunakan tanaman herbal sudah dibuktikan keberhasilannya. Sebagai upaya&#13;
pengembangan obat herbal, telah banyak penelitian yang dilakukan untuk menguji&#13;
efek antidiabetes dari ekstrak tanaman. Tujuan penelitian ini adalah melakukan&#13;
article review terkait penelitian yang menggunakan ekstrak tanaman herbal&#13;
dengan khasiat antidiabetes pada pengujian secara eksperimental menggunakan&#13;
hewan coba yang diinduksi aloksan dan streptozotosin.&#13;
Metode: Jenis penelitian yang dilakukan adalah penelitian non-eksperimental&#13;
menggunakan pendekatan artikel review yang dianalisis secara deskriptif. Artikelartikel yang direview merupakan artikel yang telah dipublikasikan pada situs&#13;
article database PubMed, Sience Direct dan Google Scholar dari tahun 2017&#13;
hingga tahun 2022.&#13;
Hasil Penelitian: Penelitian dilakukan pada 20 artikel yang menggunakan ekstrak&#13;
tanaman herbal yang berbeda-beda. Ekstrak daun kelor (Moringa oleifera) dan&#13;
ekstrak krokot (Portulaca oleracea) adalah dua ekstrak yang memiliki banyak&#13;
kandungan senyawa aktif dan efek antidiabetes yang paling baik. Senyawa aktif&#13;
ekstrak yang memiliki efek antidiabetes merupakan golongan metabolit sekunder&#13;
flavonoid, alkaloid, terpenoid, glikosida dan fenol. Didapat 4 (empat) mekanisme&#13;
kerja antidibetes dari ekstrak tanaman herbal yaitu regenerasi sel β pankreas,&#13;
penghambatan enzim α-glukosidase dan α-amilase, penghambatan enzim DPP-IV&#13;
dan peningkatan translokasi GLUT-1 dan GLUT-4.&#13;
Kesimpulan: Article Review ini dilakukan untuk mengetahui senyawa aktif dan&#13;
mekanisme kerja ekstrak tanaman herbal yang memiliki khasiat antidiabetes.&#13;
Kata Kunci: Antidiabetes, ekstrak tanaman herbal, aloksan, streptozotosin</text>
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                <text>Dian Rana Yusriyah </text>
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                <text>Poltekkes Kemenkes Palembang Jurusan Farmasi </text>
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                <text>Dr. Sonlimar Mangunsong, Apt. M.Kes</text>
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